Rabbit anti-Human, Mouse NUP155 Polyclonal Antibody | anti-NUP155 antibody

NUP155 Antibody

Cat. Num. AAA150927

• Gene Names: NUP155; N155; ATFB15
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: NUP155 Antibody is affinity chromatography purified via peptide column.
• Synonyms: NUP155; Polyclonal Antibody; NUP155 Antibody; N155; KIAA0791; Nuclear pore complex protein Nup155; 155 kDa nucleoporin; nucleoporin 155kDa; anti-NUP155 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: NUP155 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1391

• Applicable Applications for anti-NUP155 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: NUP155 antibody can be used for detection of NUP155 by Western blot at 0.5 - 1 mug/mL.
• Conjugate: Unconjugated
• Immunogen: NUP155 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human NUP155.
• Buffer: NUP155 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: NUP155 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NUP155 in P815 cell lysate with NUP155 antibody at (A) 0.5 and (B) 1 μg/mL.)

Related Product Information for anti-NUP155 antibody

NUP155 Antibody: The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. One protein in this assembly is the nucleoporin (NUP)-155, which is localized symmetrically to both the nucleoplasmic and cytoplasmic faces of the NPC. NUP155 has been reported to interact with both NUP35 and the mRNA export factor Gle1, but the functions of these interactions are still unknown. NUP155 has also been shown to be required for NPC assembly and nuclear envelope (NE) membrane fusion. NUP155 is recruited late in NE formation, suggesting that NUP155 defines an essential late step in NE assembly. NUP155 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP155 may be an important drug target in HIV treatment. At least two isoforms of NUP155 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 24430149
• NCBI GeneID: 9631
• NCBI Accession #: NP_705618
• NCBI GenBank Nucleotide #: NM_153485.2
• UniProt Accession #: O75694; Q9UBE9; Q9UFL5
• Molecular Weight: 149,016 Da
• NCBI Official Full Name: nuclear pore complex protein Nup155 isoform 1
• NCBI Official Synonym Full Names: nucleoporin 155kDa
• NCBI Official Symbol: NUP155
• NCBI Official Synonym Symbols: N155; ATFB15
• NCBI Protein Information: nuclear pore complex protein Nup155; nucleoporin 155kD; 155 kDa nucleoporin
• UniProt Protein Name: Nuclear pore complex protein Nup155
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP155
• UniProt Synonym Gene Names: KIAA0791
• UniProt Entry Name: NU155_HUMAN

NCBI Description

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

Uniprot Description

NUP155: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleoporin

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: nuclear membrane; membrane; nuclear pore; nuclear envelope

Molecular Function: structural constituent of nuclear pore; transporter activity

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; nuclear membrane organization and biogenesis; mRNA export from nucleus; protein import into nucleus; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; transmembrane transport

Disease: Atrial Fibrillation, Familial, 15