GRO-gamma Recombinant Protein | mGRO g recombinant protein

Recombinant Mouse GRO-gamma (CXCL3), His Tag

Cat. Num. AAA144927

• Gene Names: Cxcl3; Dcip1; Gm1960
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: GRO-gamma; Recombinant Mouse GRO-gamma (CXCL3); His Tag; GRO g Mouse; His; GRO-Gamma Mouse Recombinant (CXCL3); C-X-C motif chemokine 3; Dendritic cell inflammatory protein 1; Cxcl3; Dcip1; Gm1960; GRO-g; mGRO g His; mGRO g recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: GRO-gamma protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.15M NaCl and 5mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAVVAS ELRCQCLNTL PRVDFETIQS LTVTPPGPHC TQTEVIATLK DGQEVCLNPQ GPRLQIIIKK ILKSGKSS
• Sequence Length: 100

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for mGRO g recombinant protein

Description: GRO-g Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (28-100 a.a.) and having a molecular mass of 10.6kDa.CXCL3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

Product Categories/Family for mGRO g recombinant protein

Chemokines; GRO

NCBI and Uniprot Product Information

• NCBI GI #: 42600573
• NCBI GeneID: 330122
• NCBI Accession #: NP_976065.1
• NCBI GenBank Nucleotide #: NM_203320.3
• UniProt Accession #: Q6W5C0; Q3UNK9
• Molecular Weight: 10,686 Da
• NCBI Official Full Name: C-X-C motif chemokine 3
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 3
• NCBI Official Symbol: Cxcl3
• NCBI Official Synonym Symbols: Dcip1; Gm1960
• NCBI Protein Information: C-X-C motif chemokine 3; cxcl3; dendritic cell inflammatory protein 1
• UniProt Protein Name: C-X-C motif chemokine 3
• UniProt Gene Name: Cxcl3
• UniProt Entry Name: CXCL3_MOUSE

NCBI Description

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]

Uniprot Description

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; chemotaxis; inflammatory response; regulation of cell proliferation