Cathepsin-E Recombinant Protein | mCTSE recombinant protein

Recombinant Mouse Cathepsin-E

Gene Names

Ctse; CE; CatE; A430072O03Rik; C920004C08Rik

Purity

Greater than 95.0% as determined by SDS-PAGE.

Synonyms

Cathepsin-E; Recombinant Mouse Cathepsin-E; mCTSE; CTSE Mouse; Cathepsin-E Mouse Recombinant; CTSE; A430072003Rik; C920004C08Rik; CatE; CE; mCTSE recombinant protein

Ordering
Cat. Num. AAA141577 For Research Use Only!

Host

Sf9, Insect cells

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Form/Format

Sterile filtered clear solution.
CTSE protein solution (0.5mg/ml) contains PBS (pH7.4) and 10% glycerol.

Sequence

ALHRVPLRRH QSLRKKLRAQ GQLSEFWRSH NLDMTRLSES CNVYSSVNEP LINYLDMEYF GTISIGTPPQ NFTVIFDTGS SNLWVPSVYC TSPACKAHPV FHPSQSDTYT EVGNHFSIQY GTGSLTGIIG ADQVSVEGLT VDGQQFGESV KEPGQTFVNA EFDGILGLGY PSLAAGGVTP VFDNMMAQNL VALPMFSVYL SSDPQGGSGS ELTFGGYDPS HFSGSLNWIP VTKQAYWQIALDGIQVGDTV MFCSEGCQAI VDTGTSLITG PPDKIKQLQE AIGATPIDGE YAVDCATLDT MPNVTFLINE VSYTLNPTDY ILPDLVEGMQ FCGSGFQGLD IPPPAGPLWI LGDVFIRQFY SVFDRGNNQV GLAPAVPLEH HHHHH

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for mCTSE recombinant protein

CTSE or cathepsin E is an intracellular aspartic protease from the pepsin protein family. CTSE has a crucial part in protein degradation, creating bioactive proteins & processing antigens. The enzyme is responsible for cleaving at B site, Swedish mutant of amyloid precursor protein and the enzyme shows reactivity with the wild-type APP.
CTSE Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 385 amino acids (21-397 a.a.) and having a molecular mass of 41.8 kDa.CTSE is expressed with a 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Product Categories/Family for mCTSE recombinant protein

ENZYMES

NCBI and Uniprot Product Information

NCBI GI #

166235886

NCBI GeneID

13034

NCBI Accession #

NP_031825

NCBI GenBank Nucleotide #

NM_007799.3

UniProt Accession #

P70269; O35647; Q3UKT5; Q4FK00

Molecular Weight

41.8kDa (385aa) 40-57KDa (SDS-PAGE under reducing conditions.)

NCBI Official Full Name

cathepsin E preproprotein

NCBI Official Synonym Full Names

cathepsin E

NCBI Official Symbol

Ctse

NCBI Official Synonym Symbols

CE; CatE; A430072O03Rik; C920004C08Rik

NCBI Protein Information

cathepsin E

UniProt Protein Name

Cathepsin E

UniProt Gene Name

Ctse

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Uniprot Description

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Research Articles on mCTSE

1. Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.

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Product Notes

The mCTSE ctse (Catalog #AAA141577) is a Recombinant Protein produced from Sf9, Insect cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ALHRVPLRRH QSLRKKLRAQ GQLSEFWRSH NLDMTRLSES CNVYSSVNEP LINYLDMEYF GTISIGTPPQ NFTVIFDTGS SNLWVPSVYC TSPACKAHPV FHPSQSDTYT EVGNHFSIQY GTGSLTGIIG ADQVSVEGLT VDGQQFGESV KEPGQTFVNA EFDGILGLGY PSLAAGGVTP VFDNMMAQNL VALPMFSVYL SSDPQGGSGS ELTFGGYDPS HFSGSLNWIP VTKQAYWQIA LDGIQVGDTV MFCSEGCQAI VDTGTSLITG PPDKIKQLQE AIGATPIDGE YAVDCATLDT MPNVTFLINE VSYTLNPTDY ILPDLVEGMQ FCGSGFQGLD IPPPAGPLWI LGDVFIRQFY SVFDRGNNQV GLAPAVPLEH HHHHH. It is sometimes possible for the material contained within the vial of "Cathepsin-E, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.