Cathepsin E / CTSE Recombinant Protein | CTSE recombinant protein

Recombinant Mouse Cathepsin E / CTSE Protein (His tag)

Cat. Num. AAA2546915

• Gene Names: Ctse; CE; CatE; A430072O03Rik; C920004C08Rik
• Purity: > 97 % as determined by SDS-PAGE
• Synonyms: Cathepsin E / CTSE; Recombinant Mouse Cathepsin E / CTSE Protein (His tag); CH29-120A16.2; Cd152; Ctla-4; Ly-56; Ctla4; CTSE recombinant protein

• Host: Human Cells
• Purity/Purification: > 97 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 397

• Application Notes: The secreted recombinant mouse CTSE (pro form) consists of 390 amino acids and has a predicted molecular mass of 42.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCTSE is approximately 45-48 kDa due to glycosylation.
• Predicted N Terminal: Gln 19
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CTSE recombinant protein

Background: Cathepsin E Protein (CTSE Protein) is a member of the peptidase C1 family that is a gastric aspartic protease that functions as a disulfide-linked homodimer. Cathepsin E Protein (CTSE Protein) is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC classII pathway which however does not appear to be involved in the digestion of dietary protein. The protein has a specificity similar to that of pepsin and pepsin. Cathepsin E Protein (CTSE Protein) is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach and also been found in more than half of the gastric cancers. It appears, therefore, to be an oncofetal antigen.

Description: A DNA sequence encoding the extracellular domain of mouse CTSE (NP_031825.2) (Met 1-Pro 397) was expressed, with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 166235886
• NCBI GeneID: 13034
• NCBI Accession #: NP_031825.2
• NCBI GenBank Nucleotide #: NM_007799.3
• UniProt Accession #: P70269; O35647; Q3UKT5; Q4FK00
• Molecular Weight: 42,938 Da
• NCBI Official Full Name: cathepsin E preproprotein
• NCBI Official Synonym Full Names: cathepsin E
• NCBI Official Symbol: Ctse
• NCBI Official Synonym Symbols: CE; CatE; A430072O03Rik; C920004C08Rik
• NCBI Protein Information: cathepsin E
• UniProt Protein Name: Cathepsin E
• Protein Family: Cathepsin
• UniProt Gene Name: Ctse

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.34; Protease

Chromosomal Location of Human Ortholog: 1 E4|1 57.14 cM

Cellular Component: endosome

Molecular Function: aspartic-type endopeptidase activity; protein homodimerization activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein autoprocessing; protein catabolic process