4-1BB Receptor Recombinant Protein | 4-1BBR recombinant protein

Recombinant Human 4-1BB Receptor sf9

Cat. Num. AAA140733

• Gene Names: TNFRSF9; ILA; 4-1BB; CD137; CDw137
• Purity: Greater than 90.0% as determined by SDS-PAGE
• Synonyms: 4-1BB Receptor; Recombinant Human 4-1BB Receptor sf9; 4-1BBR Human; Sf9; 4-1BB Receptor Human Recombinant; Tumor Necrosis Factor Receptor Superfamily; Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor; Homolog Of Mouse Ly63; Induced By Lymphocyte Activation (ILA); Homolog Of Mouse 4-1BB; Receptor Protein 4-1BB; T Cell Antigen ILA; 4-1BB; Tumor necrosis factor receptor superfamily member 9; 4-1BBR recombinant protein

• Host: Sf9 Baculovirus Cells
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE
• Form/Format: 4-1BBR protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: ADLFERTRSLQDPCSNCPAG TFCDNNRNQI CSPCPPNSFS SAGGQRTCDI CRQCKGVFRT RKECSSTSNA ECDCTPGFHCLGAGCSMCEQ DCKQGQELTK KGCKDCCFGT FNDQKRGICR PWTNCSLDGK SVLVNGTKER DVVCGPSPADLSPGASSVTP PAPAREPGHS PQLEPKSCDKTHTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPEVKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQPREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDGSFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H.
• Sequence Length: 255

Related Product Information for 4-1BBR recombinant protein

Introduction: 4-1BBR is a member of the TNF-receptor superfamily.4-1BB receptor contributes to the clonal expansion, survival, and development of T cells.4-1BBRcan also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Description: 4-1BBR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids (18-186a.a.) and having a molecular mass of 45.3kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). 4-1BBR is expressed with a 242 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.

Product Categories/Family for 4-1BBR recombinant protein

Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 5730095
• NCBI GeneID: 3604
• NCBI Accession #: NP_001552.2
• NCBI GenBank Nucleotide #: NM_001561.5
• UniProt Accession #: Q07011; AAB34924
• Molecular Weight: 27,899 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 9
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily member 9
• NCBI Official Symbol: TNFRSF9
• NCBI Official Synonym Symbols: ILA; 4-1BB; CD137; CDw137
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 9
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 9
• UniProt Gene Name: TNFRSF9
• UniProt Synonym Gene Names: CD137; ILA
• UniProt Entry Name: TNR9_HUMAN

Uniprot Description

TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity; tumor necrosis factor receptor activity

Biological Process: apoptosis; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; regulation of apoptosis; response to lipopolysaccharide