Chondroitin sulfate proteoglycan 4 (CSPG4) Recombinant Protein | CSPG4 recombinant protein
Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4) , partial
NCBI and Uniprot Product Information
NCBI Description
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
Uniprot Description
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
Research Articles on CSPG4
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Product Notes
The CSPG4 cspg4 (Catalog #AAA1330587) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1583-2224. Partial. The amino acid sequence is listed below: SLKGSQTLTV CPGSVQPLSS QTLRASSSAG TDPQLLLYRV VRGPQLGRLF HAQQDSTGEA LVNFTQAEVY AGNILYEHEM PPEPFWEAHD TLELQLSSPP ARDVAATLAV AVSFEAACPQ RPSHLWKNKG LWVPEGQRAR ITVAALDASN LLASVPSPQR SEHDVLFQVT QFPSRGQLLV SEEPLHAGQP HFLQSQLAAG QLVYAHGGGG TQQDGFHFRA HLQGPAGASV AGPQTSEAFA ITVRDVNERP PQPQASVPLR LTRGSRAPIS RAQLSVVDPD SAPGEIEYEV QRAPHNGFLS LVGGGLGPVT RFTQADVDSG RLAFVANGSS VAGIFQLSMS DGASPPLPMS LAVDILPSAI EVQLRAPLEV PQALGRSSLS QQQLRVVSDR EEPEAAYRLI QGPQYGHLLV GGRPTSAFSQ FQIDQGEVVF AFTNFSSSHD HFRVLALARG VNASAVVNVT VRALLHVWAG GPWPQGATLR LDPTVLDAGE LANRTGSVPR FRLLEGPRHG RVVRVPRART EPGGSQLVEQ FTQQDLEDGR LGLEVGRPEG RAPGPAGDSL TLELWAQGVP PAVASLDFAT EPYNAARPYS VALLSVPEAA RTEAGKPESS TPTGEPGPMA SSPEPAVAKG GFLSFLEANM FS . It is sometimes possible for the material contained within the vial of "Chondroitin sulfate proteoglycan 4 (CSPG4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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