Protein transport protein Sec31A (SEC31A) Recombinant Protein | SEC31A recombinant protein

Recombinant Human Protein transport protein Sec31A (SEC31A) , partial

• Gene Names: SEC31A; ABP125; ABP130; HSPC275; HSPC334; SEC31L1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein transport protein Sec31A (SEC31A); Recombinant Human Protein transport protein Sec31A (SEC31A); partial; SEC31A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,166

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SEC31A recombinant protein

This protein is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 116256336
• NCBI GeneID: 22872
• NCBI Accession #: NP_001070674.1
• NCBI GenBank Nucleotide #: NM_001077206.3
• UniProt Accession #: O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; B4DIW6; B7ZKZ7; B7ZL00; H7C2W3
• Molecular Weight: 127,556 Da
• NCBI Official Full Name: protein transport protein Sec31A isoform 4
• NCBI Official Synonym Full Names: SEC31 homolog A, COPII coat complex component
• NCBI Official Symbol: SEC31A
• NCBI Official Synonym Symbols: ABP125; ABP130; HSPC275; HSPC334; SEC31L1
• NCBI Protein Information: protein transport protein Sec31A
• UniProt Protein Name: Protein transport protein Sec31A
• Protein Family: Protein transport protein
• UniProt Gene Name: SEC31A
• UniProt Synonym Gene Names: KIAA0905; SEC31L1

NCBI Description

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules ().