Western Blot (WB)
(SEC31A Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the SEC31A antibody detected the SEC31A protein (arrow).)
Rabbit anti-Mouse SEC31A Polyclonal Antibody | anti-SEC31A antibody
SEC31A Antibody (Center)
Western Blot (WB)
(SEC31A Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the SEC31A antibody detected the SEC31A protein (arrow).)
Western Blot (WB)
(SEC31A Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the SEC31A antibody detected the SEC31A protein (arrow).)
protein. Yeast Sec31 protein is known to be a component of the
COPII protein complex which is responsible for vesicle budding from
endoplasmic reticulum (ER). This protein was found to colocalize
with SEC13, one of the other components of COPII, in the
subcellular structures corresponding to the vesicle transport
function. An immunodepletion experiment confirmed that this protein
is required for ER-Golgi transport. Alternative splicing results in
multiple transcript variants encoding different isoforms. [provided
by RefSeq].
Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :
Stagg, S.M., et al. Cell 134(3):474-484(2008)
Shibata, H., et al. J. Biol. Chem. 283(15):9623-9632(2008)
Bi, X., et al. Dev. Cell 13(5):635-645(2007)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
SEC31A: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Oncoprotein
Chromosomal Location of Human Ortholog: 4q21.22
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; COPII vesicle coat; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; ER to Golgi transport vesicle; cytosol
Molecular Function: protein binding; calcium-dependent protein binding
Biological Process: COPII coating of Golgi vesicle; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; protein transport; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; response to calcium ion; post-translational protein modification
Research Articles on SEC31A
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Product Notes
The SEC31A sec31a (Catalog #AAA9214745) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 473-502. The SEC31A Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SEC31A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SEC31A sec31a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC31A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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