Lymphotactin (XCL1) Recombinant Protein | Lymphotactin recombinant protein

Human Lymphotactin (XCL1) Recombinant

Cat. Num. AAA553075

• Purity: >97%, as determined by SDS-PAGE and HPLC
• Synonyms: Lymphotactin (XCL1); Human Lymphotactin (XCL1) Recombinant; Human Lymphotatcin (XCL1) Recombinant; xcl1; ltn; lymphotactin; Lymphotactin recombinant protein

• Host: E Coli
• Purity/Purification: >97%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant Lymphotactin was lyophilzed from 0.2um filtered PBS, pH 7.0.
• Sequence: MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG
• Sequence Length: 114

• Domain: IL8
• Host Note: Optimized DNA sequence encoding Human Lymphotactin/XCL1 mature chain was expressed in Escherichia Coli.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Native human Lymphotactin has a calculated molecular mass of approximately 10 kDa. ; ; Recombinant Lymphotactin is a disulfide-linked homodimeric protein consisting of 93 amino acid residue subunits, and migrates as an approximately 10 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
• Preparation and Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.; Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for Lymphotactin recombinant protein

XCL1, also known as lymphotactin or ATAC, is the sole member of the C subgroup of chemokines, and more importantly, is produced mainly by activated CD8 T cells (and to a lesser extent by NK and mast cells). The chemotactic activity of XCL1 is restricted to lymphocytes and has no effect on monocytes.

Product Categories/Family for Lymphotactin recombinant protein

Cytokines

References

• Eotaxin-2 and colorectal cancer: a potential target for immune therapy .Clin. Cancer Res., Oct 2007; 13: 5719 - 5728.
• coexpression of il-5 and Eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma .J. Immunol., Jun 2007; 178: 7879 - 7889.
• Eotaxin-2 in sputum cell culture to evaluate asthma inflammation .Eur. Respir. J., Mar 2007; 29: 489 - 495.
• identification of a cooperative mechanism involving interleukin-13 and Eotaxin-2 in experimental allergic lung inflammation .J. Biol. Chem., Apr 2005; 280: 13952 - 13961.
• eotaxin (ccl11) and Eotaxin-2 (ccl24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers .J. Immunol., Sep 2002; 169: 2712 - 2718.