Vascular Non-Inflammatory Molecule 2 Recombinant Protein | VNN2 recombinant protein

Recombinant Human Vascular Non-Inflammatory Molecule 2 Protein

Cat. Num. AAA2556656

• Gene Names: VNN2; FOAP-4; GPI-80
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Vascular Non-Inflammatory Molecule 2; Recombinant Human Vascular Non-Inflammatory Molecule 2 Protein; Vanin-2; Glycosylphosphatidyl Inositol-Anchored Protein GPI-80; Protein FOAP-4; VNN2; VNN2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
• Sequence Length: 299

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Gln23-Ser492
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for VNN2 recombinant protein

Protein Construction: Recombinant Human Vascular Non-Inflammatory Molecule 2 is produced by our Mammalian expression system and the target gene encoding Gln23-Ser492 is expressed with a 6His tag at the C-terminus.

Background: Vascular Non-Inflammatory Molecule 2 (VNN2) is a member of the CN hydrolase family. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. VNN2 involved in the thymus homing of bone marrow cells. In addition, VNN2 may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

NCBI and Uniprot Product Information

• NCBI GI #: 334278906
• NCBI GeneID: 8875
• NCBI Accession #: NP_001229279.1
• NCBI GenBank Nucleotide #: NM_001242350.2
• UniProt Accession #: O95498; Q2XUN1; Q9UJF3; A0AUZ3; A6NDY1; A8K4E3; A8K7W0; B2DFZ0; B2DFZ1; B2DFZ2; B2DFZ3; F6XL73
• Molecular Weight: Molecular Mass: 54.2kDa; Actual Protein Molecular Mass: 68kDa
• NCBI Official Full Name: vascular non-inflammatory molecule 2 isoform 3
• NCBI Official Synonym Full Names: vanin 2
• NCBI Official Symbol: VNN2
• NCBI Official Synonym Symbols: FOAP-4; GPI-80
• NCBI Protein Information: vascular non-inflammatory molecule 2
• UniProt Protein Name: Vascular non-inflammatory molecule 2
• Protein Family: Vascular non-inflammatory molecule
• UniProt Gene Name: VNN2
• UniProt Synonym Gene Names: Vanin-2

NCBI Description

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Description

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.