Vimentin Recombinant Protein | VIM recombinant protein

Human Vimentin

Cat. Num. AAA695941

• Gene Names: VIM; HEL113; CTRCT30
• Reactivity: Species Reactivity: Human
• Purity: Above 95% as determined by SDS-PAGE Analysis.
• Synonyms: Vimentin; Human Vimentin; Recombinant Human Vimentin; VIM recombinant protein

• Host: E Coli
• Reactivity: Species Reactivity: Human
• Purity/Purification: Above 95% as determined by SDS-PAGE Analysis.
• Sequence: MSTRSVSSS SYRRMFGGP GTASRPSSS RSYVTTSTR TYSLGSALR PSTSRSLYA SSPGGVYAT RSSAVRLRS SVPGVRLLQ DSVDFSLAD AINTEFKNT RTNEKVELQ ELNDRFANY IDKVRFLEQ QNKILLAEL EQLKGQGKS RLGDLYEEE MRELRRQVD QLTNDKARV EVERDNLAE DIMRLREKL QEEMLQREE AENTLQSFR QDVDNASLA RLDLERKVE SLQEEIAFL KKLHEEEIQ ELQAQIQEQ HVQIDVDVS KPDLTAALR DVRQQYESV AAKNLQEAE EWYKSKFAD LSEAANRNN DALRQAKQE STEYRRQVQ SLTCEVDAL KGTNESLER QMREMEENF AVEAANYQD TIGRLQDEI QNMKEEMAR HLREYQDLL NVKMALDIE IATYRKLLE GEESRISLP LPNFSSLNL RETNLDSLP LVDTHSKRT LLIKTVETR DGQVINETS QHHDDLEHH HHHH

• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for VIM recombinant protein

Vimentin is a class III intermediate filament protein predominantly found in cells of mesenchymal origins, such as vascular endothelium and blood cells, where it functions as a major cytoskeletal component. Due to its importance and abundance in the cytoskeletal structure of mesenchymally-derived cells, Vimentin is frequently used as a developmental marker within cells of mesenchymal origin or cells undergoing epithelial-mesenchymal transition, which can occur during both normal and metastatic growth. An active participant within several critical processes of cellular organization and protein regulation, Vimentin is involved in the anchorage of organelles within the cytoplasmic matrix, development of astrocytes, and the disassembly of cellular components during the execution phase of apoptosis. Abnormalities in the normal physiological pathways of Vimentin have been implicated in deficient motility and directional migration involved in wound healing and cellular growth and development, as well as the adhesion-site accumulation of Vimentin on lens epithelial cells in cases of dominant cataracts. Recombinant Human Vimentin is a 54.5 kDa protein consisting of 472 amino acid residues, including a 6 residue C-terminal His-Tag.

Product Categories/Family for VIM recombinant protein

Apoptosis; Proliferation and Cell Cycle

NCBI and Uniprot Product Information

• NCBI GI #: 55977767
• NCBI GeneID: 7431
• UniProt Accession #: P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3; B0YJC2; D3DRU4
• Molecular Weight: 53,652 Da
• NCBI Official Full Name: Vimentin
• NCBI Official Synonym Full Names: vimentin
• NCBI Official Symbol: VIM
• NCBI Official Synonym Symbols: HEL113; CTRCT30
• NCBI Protein Information: vimentin; epididymis luminal protein 113
• UniProt Protein Name: Vimentin
• Protein Family: Vimentin
• UniProt Gene Name: VIM
• UniProt Entry Name: VIME_HUMAN

NCBI Description

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Uniprot Description

Vimentin: an intermediate filament protein. Intermediate filament proteins are expressed in a tissue-specific manner. Desmin is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: intermediate filament cytoskeleton; neuron projection; focal adhesion; cytoskeleton; leading edge; cytoplasm; plasma membrane; intermediate filament; peroxisome; cytosol

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; structural constituent of cytoskeleton; double-stranded RNA binding; glycoprotein binding; structural constituent of eye lens

Biological Process: Bergmann glial cell differentiation; viral reproduction; apoptosis; intermediate filament organization; cell motility; astrocyte development; cell structure disassembly during apoptosis; muscle filament sliding

Disease: Cataract 30