NKG2D Ligand 1/NKG2DL/ULBP1 Recombinant Protein | NKG2DL/ULBP1 recombinant protein

Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 Protein (C-Fc)

Cat. Num. AAA2553017

• Gene Names: ULBP1; N2DL-1; RAET1I; NKG2DL1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: NKG2D Ligand 1/NKG2DL/ULBP1; Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 Protein (C-Fc); NKG2D ligand 1; NKG2DL1; ALCAN-beta; Retinoic acid early transcript 1I; UL16-binding protein 1; ULBP1; NKG2DL/ULBP1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Gly26-Pro215
• Sequence Length: 64

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for NKG2DL/ULBP1 recombinant protein

NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess alpha1, alpha2 and alpha3 domains, ULBP/RAET1 family members lack alpha3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the immune surveillance. ULBP1 and several other family members, ULBP2 and ULBP5, own the ability to bind the human cytomegalovirus (CMV) UL16 glycoprotein. The human CMV glycoprotein UL16 binds to intracellular ULBP1 and so inhibits its expression at the cell surface, which reduces the susceptibility of the virus-infected cell to cytotoxic destruction by NK cells. The expression of ULBP1 has been found on some tumor cells and is implicated in tumor surveillance.

NCBI and Uniprot Product Information

• NCBI GI #: 952556270
• NCBI GeneID: 80329
• NCBI Accession #: NP_001304018.1
• NCBI GenBank Nucleotide #: NM_001317089.1
• UniProt Accession #: Q9BZM6; Q5VY81; Q8IZW3; Q8IZX6
• Molecular Weight: Molecular Mass: 49.4 kDa; Actual Protein Molecular Mass: 58-70 kDa
• NCBI Official Full Name: UL16-binding protein 1 isoform 2
• NCBI Official Synonym Full Names: UL16 binding protein 1
• NCBI Official Symbol: ULBP1
• NCBI Official Synonym Symbols: N2DL-1; RAET1I; NKG2DL1
• NCBI Protein Information: UL16-binding protein 1
• UniProt Protein Name: UL16-binding protein 1
• UniProt Gene Name: ULBP1
• UniProt Synonym Gene Names: N2DL1; RAET1I; N2DL-1; NKG2DL1

NCBI Description

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.