SDS-PAGE
Thioredoxin-2 / TXN2 Recombinant Protein | TXN2 recombinant protein
Recombinant Human Thioredoxin-2 / TXN2 Protein (His tag)
Gene Names
TXN2; MTRX; TRX2; MT-TRX; COXPD29
Purity
> 97 % as determined by SDS-PAGE
Synonyms
Thioredoxin-2 / TXN2; Recombinant Human Thioredoxin-2 / TXN2 Protein (His tag); RP5-1119A7. 13-005; MT-TRX; MTRX; TRX2; TXN2 recombinant protein
Host
E Coli
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 8.3
Sequence Length
166
Application Notes
The recombinant human TXN2 consisting of 118 amino acids and has a calculated molecular mass of 13.4 kDa. The apparent molecular mass of the protein is approximately 13 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Met
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for TXN2 recombinant protein
Background: Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.
Description: A DNA sequence encoding the mature form of human TXN2 (Q99757) (Thr 60-Gly 166) was expressed, with a polyhistide tag at the N-terminus.
Description: A DNA sequence encoding the mature form of human TXN2 (Q99757) (Thr 60-Gly 166) was expressed, with a polyhistide tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,383 Da
NCBI Official Full Name
thioredoxin, mitochondrial
NCBI Official Synonym Full Names
thioredoxin 2
NCBI Official Symbol
TXN2
NCBI Official Synonym Symbols
MTRX; TRX2; MT-TRX; COXPD29
NCBI Protein Information
thioredoxin, mitochondrial
UniProt Protein Name
Thioredoxin, mitochondrial
UniProt Gene Name
TXN2
UniProt Synonym Gene Names
TRX2; MTRX; Mt-Trx
NCBI Description
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Description
TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: mitochondrial matrix; mitochondrion; nucleolus
Molecular Function: protein binding
Biological Process: response to reactive oxygen species
Disease: Combined Oxidative Phosphorylation Deficiency 29
Research Articles on TXN2
Similar Products
Product Notes
The TXN2 txn2 (Catalog #AAA2545487) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human TXN2 consisting of 118 amino acids and has a calculated molecular mass of 13.4 kDa. The apparent molecular mass of the protein is approximately 13 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TXN2 txn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thioredoxin-2 / TXN2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
