Mouse tripartite motif-containing 37 ELISA Kit | TRIM37 elisa kit
Mouse E3 ubiquitin-protein ligase TRIM37, TRIM37 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]
Uniprot Description
TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Oncoprotein; Ubiquitin ligase
Cellular Component: ESC/E(Z) complex; cytoplasm; peroxisome; intracellular; cytosol
Molecular Function: protein homodimerization activity; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; ubiquitin protein ligase binding; metal ion binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; chromatin binding; tumor necrosis factor receptor binding; ligase activity
Biological Process: protein autoubiquitination; inhibition of NF-kappaB transcription factor; positive regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of centriole replication; activation of NF-kappaB transcription factor
Research Articles on TRIM37
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Product Notes
The Mouse TRIM37 trim37 (Catalog #AAA9326612) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326612 ELISA Kit recognizes Mouse TRIM37. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 37, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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