TRIM37 recombinant protein

TRIM37, Active

Cat. Num. AAA517708

• Gene Names: TRIM37; MUL; POB1; TEF3
• Applications: Western Blot
• Synonyms: TRIM37; Active; MUL; POB1; TEF3; TRIM37 recombinant protein

• Host: Sf9 insect cells
• Form/Format: Recombinant proteins stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

• Applicable Applications for TRIM37 recombinant protein: Ubiquitin Enzyme Assay, Western Blot (WB)
• Tag: GST
• Species: Human
• Preparation and Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Activity

(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)

SDS-Page

(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)

Related Product Information for TRIM37 recombinant protein

Recombinant full-length human TRIM37 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The TRIM37 gene accession number is BC036012.
TRIM37 or tripartite motif containing 37 is a member of the tripartite motif (TRIM) family whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in TRIM37 are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin.

Product Categories/Family for TRIM37 recombinant protein

Ubiquitin Enzymes; Cancer; Metabolic Disorder

References

1. Avela, K. et al: Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism. Nature Genet. 25: 298-301, 2000
2. Kallijarvi, J. et al: The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. Am. J. Hum. Genet. 70: 1215-1228, 2002

NCBI and Uniprot Product Information

• NCBI GI #: 23271191
• NCBI GeneID: 4591
• UniProt Accession #: O94972; Q7Z3E6; Q8IYF7; Q8WYF7
• Molecular Weight: ~140 kDa
• NCBI Official Full Name: Homo sapiens tripartite motif-containing 37, mRNA
• NCBI Official Synonym Full Names: tripartite motif containing 37
• NCBI Official Symbol: TRIM37
• NCBI Official Synonym Symbols: MUL; POB1; TEF3
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM37; mulibrey nanism protein; RING-B-box-coiled-coil protein; tripartite motif-containing protein 37
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM37
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRIM37
• UniProt Synonym Gene Names: KIAA0898; MUL; POB1
• UniProt Entry Name: TRI37_HUMAN

NCBI Description

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]