Rabbit anti-Mouse TRIM37 Polyclonal Antibody | anti-TRIM37 antibody

TRIM37 Polyclonal Antibody

Cat. Num. AAA2554070

• Gene Names: Trim37; MUL; TEF3; AI848587; AU043018; 1110032A10Rik; 2810004E07Rik
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: TRIM37; Polyclonal Antibody; TRIM37 Polyclonal Antibody; E3 ubiquitin protein ligase TRIM37; E3 ubiquitin-protein ligase TRIM37; KIAA0898; MUL; MUL protein; Mulibrey nanism gene; Mulibrey nanism protein; POB 1; POB1; RING B box coiled coil protein; TEF 3; TEF3; TRI37; TRIM 37; Trim37; Tripartite motif containing 37; Tripartite motif containing 37 protein; Tripartite motif containing protein 37; Tripartite motif-containing protein 37; anti-TRIM37 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• Concentration: 2 mg/mL (varies by lot)
• Sequence Length: 961

• Applicable Applications for anti-TRIM37 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant Mouse E3 ubiquitin-protein ligase TRIM37 protien
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse brain using Trim37 Polyclonal Antibody at dilution of 1:200)

Related Product Information for anti-TRIM37 antibody

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin.

Product Categories/Family for anti-TRIM37 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 37574064
• NCBI GeneID: 68729
• NCBI Accession #: NP_932104.1
• NCBI GenBank Nucleotide #: NM_197987.2
• UniProt Accession #: Q6PCX9; Q5SX31; Q8CHC5
• Molecular Weight: 107,660 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM37 isoform 2
• NCBI Official Synonym Full Names: tripartite motif-containing 37
• NCBI Official Symbol: Trim37
• NCBI Official Synonym Symbols: MUL; TEF3; AI848587; AU043018; 1110032A10Rik; 2810004E07Rik
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM37
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM37
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Trim37

NCBI Description

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]

Uniprot Description

E3 ubiquitin-protein ligase required to prevent centriole reduplication (). Probably acts by ubiquitinating positive regulators of centriole reduplication (). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).