Human TLT1 ELISA Kit | TREML1 elisa kit

Human TLT1 ELISA Kit

Cat. Num. AAA8248413

• Gene Names: TREML1; TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• Reactivity: Human
• Synonyms: TLT1; Human TLT1 ELISA Kit; Trem-like transcript 1 protein; TLT-1; Triggering receptor expressed on myeloid cells-like protein 1; TREML1 elisa kit

• Reactivity: Human
• Specificity: The Human TLT1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TLT1 proteins within the range of 15.6 pg/ml - 1000 pg/ml.
• Sequence Length: 199

• Samples: Cell Culture Supernates, Serum, Plasma
• Sensitivity: <10 pg/ml
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TREML1 elisa kit

Principle of the Assay: The Human TLT1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human TLT1 in Cell Culture Supernates, Serum, Plasma. This assay employs an antibody specific for Human TLT1 coated on a 96-well plate. Standards and samples are pipetted into the wells and TLT1 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human TLT1 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of TLT1 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background: Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene. This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. This protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 424036738
• NCBI GeneID: 340205
• NCBI Accession #: NP_001258736.1
• NCBI GenBank Nucleotide #: NM_001271807.1
• UniProt Accession #: Q86YW5; Q496B3; Q8IWY1; Q8IWY2
• Molecular Weight: 20,731 Da
• NCBI Official Full Name: trem-like transcript 1 protein isoform b
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells like 1
• NCBI Official Symbol: TREML1
• NCBI Official Synonym Symbols: TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• NCBI Protein Information: trem-like transcript 1 protein
• UniProt Protein Name: Trem-like transcript 1 protein
• Protein Family: Trem-like transcript 1 protein
• UniProt Gene Name: TREML1
• UniProt Synonym Gene Names: TLT1; TLT-1
• UniProt Entry Name: TRML1_HUMAN

NCBI Description

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Uniprot Description

TREML1: Cell surface receptor that may play a role in the innate and adaptive immune response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Biological Process: regulation of immune response