TLT-1/TREML1 Recombinant Protein | TREML1 recombinant protein

TLT-1/TREML1 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121018

• Gene Names: TREML1; TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• Purity: >90% as determined by SDS-PAGE
• Synonyms: TLT-1/TREML1; TLT-1/TREML1 Protein; Human; Recombinant (His Tag); Human TREML1/TLT-1 Protein (His Tag); dJ238O23.3 Protein; GLTL1825 Protein; MGC119173 Protein; PRO3438 Protein; TLT-1 Protein; TLT1 Protein; UNQ1825/PRO3438 Protein; triggering receptor expressed on myeloid cells like 1; TREML1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Pro162

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 16
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human TREML1 isoform 1 (Q86YW5-1) extracellular domain (Met 1-Pro 162) was expressed, with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for TREML1 recombinant protein

Background: Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1/TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1/TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte/macrophages, and dendritic cells, via their association with DAP12. TREML1/TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1/TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.

Product Categories/Family for TREML1 recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Washington A.V., et al., 2002, Blood 100:3822-4. Allcock R.J.N., et al., 2003, Eur. J. Immunol. 33:567-77. Washington A.V., et al., 2004, Blood 104:1042-7. Barrow A.D., et al., 2004, J. Immunol. 172:5838-42. Gattis J.L., et al., 2006,J. Biol. Chem. 281:13396-403.

NCBI and Uniprot Product Information

• NCBI GI #: 424036738
• NCBI GeneID: 340205
• NCBI Accession #: NP_001258736.1
• NCBI GenBank Nucleotide #: NM_001271807.1
• UniProt Accession #: Q86YW5; Q496B3; Q8IWY1; Q8IWY2
• Molecular Weight: 20,731 Da
• NCBI Official Full Name: trem-like transcript 1 protein isoform b
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells like 1
• NCBI Official Symbol: TREML1
• NCBI Official Synonym Symbols: TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• NCBI Protein Information: trem-like transcript 1 protein
• UniProt Protein Name: Trem-like transcript 1 protein
• Protein Family: Trem-like transcript 1 protein
• UniProt Gene Name: TREML1
• UniProt Synonym Gene Names: TLT1; TLT-1
• UniProt Entry Name: TRML1_HUMAN

NCBI Description

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Uniprot Description

TREML1: Cell surface receptor that may play a role in the innate and adaptive immune response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Biological Process: regulation of immune response