Translationally-controlled tumor Recombinant Protein | Tpt1 recombinant protein

Recombinant Mouse Translationally-controlled tumor protein

Cat. Num. AAA956588

• Gene Names: Tpt1; Trt; p21; p23; TCTP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Translationally-controlled tumor; Recombinant Mouse Translationally-controlled tumor protein; 21 kDa polypeptide; p21; p23; Tpt1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-172aa; Full Length
• Sequence: MIIYRDLISHDELFSDIYKIREIADGLCLEVEGKMVSRTEGAIDDSLIGGNASAEGPEGEGTESTVVTGVDIVMNHHLQETSFTKEAYKKYIKDYMKSLKGKLEEQKPERVKPFMTGAAEQIKHILANFNNYQFFIGENMNPDGMVALLDYREDGVTPFMIFFKDGLEMEKC

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Tpt1 recombinant protein

Involved in calcium binding and microtubule stabilization.

References

Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells.Makrides S., Chitpatima S.T., Bandyopadhyay R., Brawerman G.Nucleic Acids Res. 16:2350-2350(1988) The growth-related protein P23 of the Ehrlich ascites tumor translational control, cloning and primary structure.Boehm H., Beendorf R., Gaestel M., Gross B., Nuernberg P., Kraft R., Otto A., Bielka H.Biochem. Int. 19:277-286(1989) Genomic organization and expression of mouse Tpt1 gene.Fiucci G., Lespagnol A., Stumptner-Cuvelette P., Beaucourt S., Duflaut D., Susini L., Amson R., Telerman A.Genomics 81:570-578(2003) Lubec G., Klug S., Yang J.W., Zigmond M.Submitted (JUL-2007) to UniProtKB

NCBI and Uniprot Product Information

• NCBI GI #: 6678437
• NCBI GeneID: 22070
• NCBI Accession #: NP_033455.1
• NCBI GenBank Nucleotide #: NM_009429.3
• UniProt Accession #: P63028; P14701; Q3TMT0; Q3TWS8; Q3TWX0; Q3UAG7; Q569M9
• Molecular Weight: 21.5 kDa
• NCBI Official Full Name: translationally-controlled tumor protein
• NCBI Official Synonym Full Names: tumor protein, translationally-controlled 1
• NCBI Official Symbol: Tpt1
• NCBI Official Synonym Symbols: Trt; p21; p23; TCTP
• NCBI Protein Information: translationally-controlled tumor protein
• UniProt Protein Name: Translationally-controlled tumor protein
• Protein Family: tRNA 2'-phosphotransferase
• UniProt Gene Name: Tpt1
• UniProt Synonym Gene Names: Trt; TCTP
• UniProt Entry Name: TCTP_MOUSE

Uniprot Description

TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.

Protein type: Microtubule-binding; Calcium-binding

Cellular Component: cytoplasm; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complex

Molecular Function: calcium ion binding; protein binding; transcription factor binding

Biological Process: stem cell maintenance