Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Tumor Protein, Translationally Controlled 1 (TPT1) Polyclonal Antibody | anti-TPT1 antibody
Polyclonal Antibody to Tumor Protein, Translationally Controlled 1 (TPT1)
MGHHHHHHSGSEF- MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD YREDGVTPFM IFFKDGLEME KC
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.
Protein type: Calcium-binding; Microtubule-binding
Chromosomal Location of Human Ortholog: 14 D3|14 40.29 cM
Cellular Component: cytoplasm; cytosol; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complex
Molecular Function: calcium ion binding; microtubule binding; protein binding; RNA binding; transcription factor binding
Biological Process: cell differentiation; stem cell maintenance
Research Articles on TPT1
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Product Notes
The TPT1 tpt1 (Catalog #AAA2004072) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Tumor Protein, Translationally Controlled 1 (TPT1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Tumor Protein, Translationally Controlled 1 (TPT1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the TPT1 tpt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD YREDGVTPFM IFFKDGLEME KC. It is sometimes possible for the material contained within the vial of "Tumor Protein, Translationally Controlled 1 (TPT1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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