TPO recombinant protein

Purified recombinant TPO protein (His tag)

Cat. Num. AAA5308988

• Gene Names: TPO; MSA; TPX; TDH2A
• Purity: > 85% pure; Purified using proprietary chromatographic techniques
• Synonyms: TPO; Purified recombinant TPO protein (His tag); TPO protein (His tag); TPO recombinant protein

• Host: Human
• Purity/Purification: > 85% pure; Purified using proprietary chromatographic techniques
• Form/Format: Supplied in 50mM Tris buffer, pH 8.5, 400mM NaCl, 0.1mM KI, 10% glycerol and 10mM beta-Me
• Sequence Length: 16-837 aa

• Expression: Baculovirus
• Tag: His tag
• Dry Ice Shipment: Extra charge may be applied to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Product Categories/Family for TPO recombinant protein

Proteases; Inhibitors; Enzymes; Conjugated Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 332078492
• NCBI GeneID: 7173
• NCBI Accession #: NP_001193674.1
• NCBI GenBank Nucleotide #: NM_001206745.1
• UniProt Accession #: P07202; P09934; P09935; Q8IUL0; Q8NF94; Q8NF95; Q8NF96; Q8NF97; Q8TCI9
• Molecular Weight: 92,063 Da
• NCBI Official Full Name: thyroid peroxidase isoform b
• NCBI Official Synonym Full Names: thyroid peroxidase
• NCBI Official Symbol: TPO
• NCBI Official Synonym Symbols: MSA; TPX; TDH2A
• NCBI Protein Information: thyroid peroxidase
• UniProt Protein Name: Thyroid peroxidase
• Protein Family: Thyroid peroxidase
• UniProt Gene Name: TPO
• UniProt Synonym Gene Names: TPO

NCBI Description

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Uniprot Description

TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.11.1.8; Membrane protein, integral; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: peroxidase activity

Biological Process: embryonic hemopoiesis; thyroid hormone generation

Disease: Thyroid Dyshormonogenesis 2a