Human topoisomerase I binding, arginine/serine-rich ELISA Kit | TOPORS elisa kit
Human E3 ubiquitin-protein ligase Topors, TOPORS ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Uniprot Description
TOPORS: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation. Interacts with PARK7/DJ-1. Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinate and sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage. By genotoxic agents such as cisplatin and camptothecin. Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Cell cycle regulation; Ligase
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: centriole; spindle pole; PML body; cytoplasmic dynein complex; nuclear speck; midbody; nucleus; ubiquitin ligase complex; photoreceptor connecting cilium; gamma-tubulin complex
Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; antigen binding; SUMO ligase activity; ligase activity
Biological Process: protein monoubiquitination; ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; retinal rod cell development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of cell proliferation; protein sumoylation; DNA damage response, signal transduction resulting in induction of apoptosis; retinal cone cell development; positive regulation of ubiquitin-protein ligase activity; maintenance of protein localization in nucleus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; negative regulation of apoptosis
Disease: Retinitis Pigmentosa 31
Research Articles on TOPORS
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Product Notes
The Human TOPORS topors (Catalog #AAA9316498) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316498 ELISA Kit recognizes Human TOPORS. It is sometimes possible for the material contained within the vial of "topoisomerase I binding, arginine/serine-rich, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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