CD137L recombinant protein

CD137L (soluble) (human), (recombinant)

Cat. Num. AAA566248

• Gene Names: Tnfsf9; Ly63l; 4-1BBL; Cd137l; 4-1BB-L; AI848817
• Purity: >=95% (SDS-PAGE)
• Synonyms: CD137L; CD137L (soluble) (human); (recombinant); CD137L recombinant protein

• Host: HEK293 cells
• Specificity: Binds to human CD137 (4-1BB)
• Purity/Purification: >=95% (SDS-PAGE)
• Form/Format: Lyophilized. Contains PBS and 5% trehalose
• Concentration: 0.1mg/ml after reconstitution (varies by lot)

• Source Note: The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a DYKDDDDK-tag
• Endotoxin: <0.1EU/ug purified protein (LAL test)
• Reconstitution: Reconstitute with 100ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum
• Preparation and Storage: Stable for at least 6 months after receipt when stored at -20 degree C; Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C; Shipping: Shipped on Blue Ice

Related Product Information for CD137L recombinant protein

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56^lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

Product Categories/Family for CD137L recombinant protein

Cellular Analysis; Cell & Tissue Markers

NCBI and Uniprot Product Information

• NCBI GI #: 6678389
• NCBI GeneID: 21950
• NCBI Accession #: NP_033430.1
• NCBI GenBank Nucleotide #: NM_009404.3
• UniProt Accession #: P41274
• Molecular Weight: 33,853 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 9
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 9
• NCBI Official Symbol: Tnfsf9
• NCBI Official Synonym Symbols: Ly63l; 4-1BBL; Cd137l; 4-1BB-L; AI848817
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 9; 4-1BB ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 9
• UniProt Gene Name: Tnfsf9
• UniProt Synonym Gene Names: Cd137l; Cd157l; Ly63l; 4-1BBL
• UniProt Entry Name: TNFL9_MOUSE

Uniprot Description

TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral; Cell cycle regulation

Cellular Component: extracellular space; membrane; integral to membrane; plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: positive regulation of interferon-gamma production; positive regulation of cytotoxic T cell differentiation; cell-cell signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; myeloid dendritic cell differentiation; immune response; positive regulation of activated T cell proliferation; regulation of cell proliferation