TNFRSF17 / BCMA recombinant protein

Recombinant Mouse TNFRSF17 / BCMA Protein (His & Fc tag)

Cat. Num. AAA2547235

• Gene Names: Tnfrsf17; BCM; BCMA; Tnfrsf13; Tnfrsf13a
• Purity: > 90 % as determined by SDS-PAGE
• Synonyms: TNFRSF17 / BCMA; Recombinant Mouse TNFRSF17 / BCMA Protein (His & Fc tag); Tnfrsf17; BCM; BCMA; Tnfrsf13; Tnfrsf13a; TNFRSF17 / BCMA recombinant protein

• Host: Human Cells
• Purity/Purification: > 90 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 185

• Application Notes: The recombinant mouse BCMA/Fc chimera is a disulfide-linked homodimer The reduced monomer consists of 297 amino acids and has a predicted molecular mass of 33.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm BCMA/Fc monomer is approximately 35-48 kDa due to glycosylation.
• Predicted N Terminal: Glu 20
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for TNFRSF17 / BCMA recombinant protein

Background: Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

Description: A DNA sequence encoding the extracellular domain of mouse BCMA (NP_035738.1) (Met 1-Thr 49) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 6755823
• NCBI GeneID: 21935
• NCBI Accession #: NP_035738.1
• NCBI GenBank Nucleotide #: NM_011608.1
• UniProt Accession #: O88472
• Molecular Weight: 19,932 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 17
• NCBI Official Symbol: Tnfrsf17
• NCBI Official Synonym Symbols: BCM; BCMA; Tnfrsf13; Tnfrsf13a
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• UniProt Gene Name: Tnfrsf17
• UniProt Synonym Gene Names: Bcm; Bcma

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Membrane protein, integral; Oncoprotein; Receptor, misc.

Chromosomal Location of Human Ortholog: 16|16 A1

Biological Process: lymphocyte homeostasis