BCMA Recombinant Protein | TNFRSF17 recombinant protein

BCMA Protein, Mouse, Recombinant (hFc Tag)

Cat. Num. AAA8122520

• Gene Names: Tnfrsf17; BCM; BCMA; Tnfrsf13; Tnfrsf13a
• Purity: >95% as determined by SDS-PAGE
• Synonyms: BCMA; BCMA Protein; Mouse; Recombinant (hFc Tag); Mouse TNFRSF17/BCMA Protein (Fc Tag); BCM Protein; Tnfrsf13 Protein; Tnfrsf13a Protein; tumor necrosis factor receptor superfamily member 17; TNFRSF17 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Thr49

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Glu 20
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the extracellular domain (Met 1-Thr 49) of mouse BCMA (NP_035738.1) precursor was fused with the Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for TNFRSF17 recombinant protein

Background: Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

References

Novak AJ, et al. (2004) Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood. 103 (2): 689-94.O'Connor BP, et al. (2004) BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med. 199(1): 91-8.Moser K, et al. (2006) Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol. 18(3): 265-70.

NCBI and Uniprot Product Information

• NCBI GI #: 6755823
• NCBI GeneID: 21935
• NCBI Accession #: NP_035738.1
• NCBI GenBank Nucleotide #: NM_011608.1
• UniProt Accession #: O88472
• Molecular Weight: 19,932 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 17
• NCBI Official Symbol: Tnfrsf17
• NCBI Official Synonym Symbols: BCM; BCMA; Tnfrsf13; Tnfrsf13a
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Tnfrsf17
• UniProt Synonym Gene Names: Bcm; Bcma
• UniProt Entry Name: TNR17_MOUSE

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Membrane protein, integral; Receptor, misc.; Oncoprotein

Cellular Component: membrane; integral to membrane

Biological Process: immune system process; lymphocyte homeostasis