Testing Data
DcR1/TRAILR3 Recombinant Protein | TNFRSF10C recombinant protein
DcR1/TRAILR3 Protein, Human, Recombinant (His Tag)
Gene Names
TNFRSF10C; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
Purity
>95 % as determined by SDS-PAGE.
Synonyms
DcR1/TRAILR3; DcR1/TRAILR3 Protein; Human; Recombinant (His Tag); Human TRAILR3/TNFRSF10C Protein (His Tag); tumor necrosis factor receptor superfamily member 10c; CD263 Protein; DCR1 Protein; DCR1-TNFR Protein; LIT Protein; TRAIL-R3 Protein; TRAILR3 Protein; TRID Protein; TNFRSF10C recombinant protein
Host
HEK293 Cells
Purity/Purification
>95 % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Sequence Positions
221aa
Sequence
Met1-Pro235
Species
Human
Tag
C-His
Endotoxin
<1.0EU per ug protein as determined by the LAL method
Predicted N Terminal
Ala26
Protein Construction
|A DNA sequence encoding the human TNFRSF10C (NP_003832.2) (Met1-Pro235) was expressed with a polyhistidine tag at the C-terminus
Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized human TNFRSF10C (Cat:10415-H08H) at 10ug/mL (100uL/well) can bind biotinylated human TNFSF10 (10409-HNAE). The EC50 of biotinylated human TNFSF10 is 0.1-0.7ug/mL.
2. Immobilized human TNFRSF10C (Cat:10415-H08H) at 10ug/mL (100uL/well) can bind biotinylated human TNFSF10 (10409-HNAE). The EC50 of biotinylated human TNFSF10 is 0.1-0.7ug/mL.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping: They are shipped out with blue ice pack
Shipping: They are shipped out with blue ice pack
Testing Data
Testing Data
Testing Data
(Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10C(Cat: 10415-H08H) at 10ug/mL (100uL/well) can bind biotinylated human TNFSF10 (10409-HNAE), the EC50 of biotinylated human TNFSF10 is 0.1-0.7 ug/mL.)
Testing Data
(Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10C(Cat: 10415-H08H) at 10ug/mL (100uL/well) can bind biotinylated human TNFSF10 (10409-HNAE), the EC50 of biotinylated human TNFSF10 is 0.1-0.7 ug/mL.)
Related Product Information for TNFRSF10C recombinant protein
TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a marker and a new therapeutic approach for PC.
Product Categories/Family for TNFRSF10C recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,407 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10C
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily member 10c
NCBI Official Symbol
TNFRSF10C
NCBI Official Synonym Symbols
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10C
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10C
Protein Family
UniProt Gene Name
TNFRSF10C
UniProt Synonym Gene Names
DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
UniProt Entry Name
TR10C_HUMAN
Uniprot Description
TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 8p22-p21
Cellular Component: integral to plasma membrane
Molecular Function: transmembrane receptor activity; TRAIL binding
Biological Process: apoptosis; signal transduction
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Product Notes
The TNFRSF10C tnfrsf10c (Catalog #AAA8118630) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 221aa. The amino acid sequence is listed below: Met1-Pro23 5. It is sometimes possible for the material contained within the vial of "DcR1/TRAILR3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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