Transmembrane protease serine 3 (Tmprss3) Recombinant Protein | Tmprss3 recombinant protein

Recombinant Mouse Transmembrane protease serine 3 (Tmprss3), partial

Cat. Num. AAA1444479

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transmembrane protease serine 3 (Tmprss3); Recombinant Mouse Transmembrane protease serine 3 (Tmprss3); partial; Tmprss3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 70-453
• Sequence: H FDCSGKYRCH SSFKCIELTA RCDGVSDCKN AEDEYRCVRV SGQRAALQVF TAAAWRTMCS DDWKSHYAKI ACAQLGFPSY VSSDHLRVDA LEEQFQGDFV SINHLLSDDK VTALHHSVYM REGCTSGHVV TLKCSACGTR TGYSPRIVGG NMSSLTQWPW QVSLQFQGYH LCGGSIITPL WIVTAAHCVY DLYHPKSWTV QVGLVSLMDS PVPSHLVEKI IYHSKYKPKR LGNDIALMKL SEPLTFDETI QPICLPNSEE NFPDGKLCWT SGWGATEDGG DASPVLNHAA VPLISNKICN HRDVYGGIIS PSMLCAGYLK GGVDSCQGDS GGPLVCQERR LWKLVGATSF GIGCAEVNKP GVYTRITSFL DWIHEQLERD LKT
• Sequence Length: 384

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Tmprss3 recombinant protein

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 255003692
• NCBI GeneID: 140765
• NCBI Accession #: NP_542765.2
• NCBI GenBank Nucleotide #: NM_080727.2
• UniProt Accession #: Q8K1T0; Q812A6; Q8VDE0
• Molecular Weight: 51,886 Da
• NCBI Official Full Name: transmembrane protease serine 3 isoform 2
• NCBI Official Synonym Full Names: transmembrane protease, serine 3
• NCBI Official Symbol: Tmprss3
• NCBI Protein Information: transmembrane protease serine 3
• UniProt Protein Name: Transmembrane protease serine 3
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: Tmprss3

Uniprot Description

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro).