Immunohistochemistry (IHC)
(Anti-SLC22A4 / OCTN1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit anti-Human SLC22A4 / OCTN1 Polyclonal Antibody | anti-SLC22A4 antibody
Rabbit Polyclonal to Human SLC22A4 / OCTN1
Immunohistochemistry (IHC)
(Anti-SLC22A4 / OCTN1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-SLC22A4 / OCTN1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-SLC22A4 / OCTN1 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
Immunohistochemistry (IHC)
(Anti-SLC22A4 / OCTN1 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
Western Blot (WB)
(SLC22A4 Antibody (C-term) Western blot of HeLa,K562 cell line lysates (35 ug/lane). This demonstrates the SLC22A4 antibody detected the SLC22A4 protein (arrow).)
Western Blot (WB)
(SLC22A4 Antibody (C-term) Western blot of HeLa,K562 cell line lysates (35 ug/lane). This demonstrates the SLC22A4 antibody detected the SLC22A4 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Uniprot Description
SLC22A4: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein type: Mitochondrial; Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: mitochondrion; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: protein binding; cation:cation antiporter activity; symporter activity; nucleotide binding; carnitine transporter activity; secondary active organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding
Biological Process: organic cation transport; triacylglycerol metabolic process; quaternary ammonium group transport; sodium ion transport; carnitine metabolic process; body fluid secretion; transmembrane transport; carnitine transport
Disease: Rheumatoid Arthritis
Research Articles on SLC22A4
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Product Notes
The SLC22A4 slc22a4 (Catalog #AAA248008) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human SLC22A4 / OCTN1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC22A4 / OCTN1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (1:50), WB (1:1000). Researchers should empirically determine the suitability of the SLC22A4 slc22a4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC22A4 / OCTN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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