TMPRSS11D recombinant protein

TMPRSS11D Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121259

• Gene Names: TMPRSS11D; HAT
• Purity: >95% as determined by SDS-PAGE
• Synonyms: TMPRSS11D; TMPRSS11D Protein; Human; Recombinant (His Tag); Human TMPRSS11D protein (His Tag); HAT Protein; transmembrane protease; serine 11D; TMPRSS11D recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ile187-Ile417

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human TMPRSS11D (NP_004253.1)(Ile187-Ile417) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for TMPRSS11D recombinant protein

Background: TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. Both TMPRSS11D mRNA and protein expression levels were significantly higher in NSCLC tumorous tissues than in adjacent normal tissues. High TMPRSS11D protein expression was associated with high TNM stages, and high TMPRSS11D protein expression is an independent prognostic marker in NSCLC.

Product Categories/Family for TMPRSS11D recombinant protein

Serine Proteases and Regulators

NCBI and Uniprot Product Information

• NCBI GI #: 4758508
• NCBI GeneID: 9407
• NCBI Accession #: NP_004253.1
• NCBI GenBank Nucleotide #: NM_004262.2
• UniProt Accession #: O60235; Q08AF6
• Molecular Weight: 46,263 Da
• NCBI Official Full Name: transmembrane protease serine 11D
• NCBI Official Synonym Full Names: transmembrane protease, serine 11D
• NCBI Official Symbol: TMPRSS11D
• NCBI Official Synonym Symbols: HAT
• NCBI Protein Information: transmembrane protease serine 11D
• UniProt Protein Name: Transmembrane protease serine 11D
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS11D
• UniProt Synonym Gene Names: HAT
• UniProt Entry Name: TM11D_HUMAN

NCBI Description

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]