Thymidine kinase Recombinant Protein | TK1 recombinant protein

Recombinant Human herpesvirus 1 Thymidine kinase

Cat. Num. AAA959745

• Gene Names: TK1; TK2
• Applications: Calibrator/Standard
• Purity: 85% ± 5% by SDS-PAGE
• Synonyms: Thymidine kinase; Recombinant Human herpesvirus 1 Thymidine kinase; TK1 recombinant protein

• Host: E.coli
• Purity/Purification: 85% ± 5% by SDS-PAGE
• Form/Format: Liquid, dissolved in 20mM Tris-HCl, 500mM NaCl, pH 8.0, 50% glycerol
• Sequence Positions: 1-376
• Sequence: MASYPCHQHASAFDQAARSRGHNNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN

• Applicable Applications for TK1 recombinant protein: Calibrator/Standard
• Tag: his-tag
• Product Note: Applications are user defined. Product is developed and quality control tested in house, data or additional information may be provided upon request. The researcher needs to establish and confirm the suitability of the product for their application.
• Preparation and Storage: Store: Aliquot and store at < or = 20 degree C. Avoid repeated freeze/thaw cycles; -20 degree C for one year.

SDS-Page

Product Categories/Family for TK1 recombinant protein

Epigenetics and Nuclear Signaling; Raw Materials Assay Development

References

Human thymidine kinase gene molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.Bradshaw H.D. Jr., Deininger P.L.Mol. Cell. Biol. 4:2316-2320(1984)

NCBI and Uniprot Product Information

• NCBI GI #: 164698438
• NCBI GeneID: 7083
• NCBI Accession #: NP_003249.3
• NCBI GenBank Nucleotide #: NM_003258.4
• UniProt Accession #: P04183; Q969V0; Q9UMG9; B2RC58
• Molecular Weight: 41.32kD
• NCBI Official Full Name: thymidine kinase, cytosolic
• NCBI Official Synonym Full Names: thymidine kinase 1, soluble
• NCBI Official Symbol: TK1
• NCBI Official Synonym Symbols: TK2
• NCBI Protein Information: thymidine kinase, cytosolic
• UniProt Protein Name: Thymidine kinase, cytosolic
• Protein Family: Thymidine kinase
• UniProt Gene Name: TK1
• UniProt Entry Name: KITH_HUMAN

Uniprot Description

TK: cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Protein type: EC 2.7.1.21; Xenobiotic Metabolism - drug metabolism - other enzymes; Kinase, other; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 17q23.2-q25.3

Cellular Component: cytosol

Molecular Function: ATP binding; identical protein binding; nucleoside kinase activity; protein binding; thymidine kinase activity; zinc ion binding

Biological Process: deoxyribonucleoside monophosphate biosynthetic process; fetal process involved in parturition; gut development; liver development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide biosynthetic process; phosphorylation; protein homotetramerization; pyrimidine base metabolic process; pyrimidine nucleoside salvage; response to copper ion; response to cortisol stimulus; response to nutrient levels; response to toxin; skeletal muscle cell proliferation; thymidine metabolic process