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Fc receptor-like protein 4 Recombinant Protein | FCRL4 recombinant protein
Recombinant Human Fc receptor-like protein 4
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Uniprot Description
FCRL4: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding
Biological Process: adaptive immune response
Research Articles on FCRL4
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Product Notes
The FCRL4 fcrl4 (Catalog #AAA1327975) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-387. Partial, provide the complete extracellular domain. The amino acid sequence is listed below: AHKPVISVHP PWTTFFKGER VTLTCNGFQF YATEKTTWYH RHYWGEKLTL TPGNTLEVRE SGLYRCQARG SPRSNPVRLL FSSDSLILQA PYSVFEGDTL VLRCHRRRKE KLTAVKYTWN GNILSISNKS WDLLIPQASS NNNGNYRCIG YGDENDVFRS NFKIIKIQEL FPHPELKATD SQPTEGNSVN LSCETQLPPE RSDTPLHFNF FRDGEVILSD WSTYPELQLP TVWRENSGSY WCGAETVRGN IHKHSPSLQI HVQRIPVSGV LLETQPSGGQ AVEGEMLVLV CSVAEGTGDT TFSWHREDMQ ESLGRKTQRS LRAELELPAI RQSHAGGYYC TADNSYGPVQ SMVLNVTVRE TPGNRDGL. It is sometimes possible for the material contained within the vial of "Fc receptor-like protein 4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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