Tissue Inhibitors of Metallo Proteinases 1/TIMP1 Recombinant Protein | TIMP1 recombinant protein

Recombinant Mouse Tissue Inhibitors of Metallo Proteinases 1/TIMP1 Protein

Cat. Num. AAA2553629

• Gene Names: Timp1; EPA; Clgi; Timp; TIMP-1; TPA-S1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Tissue Inhibitors of Metallo Proteinases 1/TIMP1; Recombinant Mouse Tissue Inhibitors of Metallo Proteinases 1/TIMP1 Protein; Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; Collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP; TIMP1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
• Sequence Positions: Cys25-Arg205
• Sequence Length: 205

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for TIMP1 recombinant protein

Mouse Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Timp-1 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. It also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16, without MMP-14.

NCBI and Uniprot Product Information

• NCBI GI #: 113205063
• NCBI GeneID: 21857
• NCBI Accession #: NP_001037849.1
• NCBI GenBank Nucleotide #: NM_001044384.1
• UniProt Accession #: P12032; P20064; Q61720
• Molecular Weight: Molecular Mass: 20.2 kDa; Actual Protein Molecular Mass: 26 kDa
• NCBI Official Full Name: metalloproteinase inhibitor 1 isoform a
• NCBI Official Synonym Full Names: tissue inhibitor of metalloproteinase 1
• NCBI Official Symbol: Timp1
• NCBI Official Synonym Symbols: EPA; Clgi; Timp; TIMP-1; TPA-S1
• NCBI Protein Information: metalloproteinase inhibitor 1
• UniProt Protein Name: Metalloproteinase inhibitor 1
• Protein Family: Metalloproteinase inhibitor
• UniProt Gene Name: Timp1
• UniProt Synonym Gene Names: Timp; Timp-1; EPA; TIMP-1

Uniprot Description

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.