Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas using MBS7001732 at dilution 1:100)
Rabbit anti-Human Glutamate receptor ionotropic, NMDA 2A Polyclonal Antibody | anti-GRIN2A antibody
Rabbit anti-human Glutamate receptor ionotropic, NMDA 2A polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas using MBS7001732 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human pancreas using MBS7001732 at dilution 1:100)
Western Blot (WB)
(Western BlotPositive WB detected in: U87 whole cell lysate,Rat heart tissue,Mouse liver tissueAll lanes: GRIN2A antibody at 3.2ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 166,145 KDaObserved band size: 166 KDa)
Western Blot (WB)
(Western BlotPositive WB detected in: U87 whole cell lysate,Rat heart tissue,Mouse liver tissueAll lanes: GRIN2A antibody at 3.2ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 166,145 KDaObserved band size: 166 KDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component: cell junction; cell surface; endoplasmic reticulum; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane; presynaptic membrane; synaptic vesicle
Molecular Function: calcium channel activity; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; zinc ion binding
Biological Process: activation of MAPKK activity; axon guidance; directional locomotion; dopamine metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glutamate signaling pathway; innate immune response; insulin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; memory; negative regulation of protein catabolic process; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; protein localization; Ras protein signal transduction; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to amphetamine; response to drug; response to ethanol; response to wounding; sensory perception of pain; serotonin metabolic process; sleep; small GTPase mediated signal transduction; startle response; synaptic transmission; transport; vascular endothelial growth factor receptor signaling pathway; visual learning
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Research Articles on GRIN2A
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Product Notes
The GRIN2A grin2a (Catalog #AAA7001732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Glutamate receptor ionotropic, NMDA 2A polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Glutamate receptor ionotropic, NMDA 2A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC: 1:20-1:200. Researchers should empirically determine the suitability of the GRIN2A grin2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glutamate receptor ionotropic, NMDA 2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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