TIE-1 Fc Chimera Recombinant Protein | mTIE-1 Fc recombinant protein
Recombinant Mouse TIE-1 Fc Chimera
Gene Names
Tie1; TIE; tie-1; D430008P04Rik
Purity
Greater than 90.0% as determined by SDS-PAGE.
Synonyms
TIE-1 Fc Chimera; Recombinant Mouse TIE-1 Fc Chimera; TIE1 Fc Mouse; TIE1 Fc Chimera Mouse Recombinant; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1; JTK14; TIE; TIE1; mTIE-1 Fc recombinant protein
Host
Chinese Hamster Ovarian Cells (CHO)
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
TIE-1 Fc Chimera was lyophilized from a concentrated (1 mg/ml) sterile solution containing 1x PBS.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence Length
1134
Solubility
It is recommended to reconstitute the lyophilized TIE-1 Fc Chimera in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized sTIE-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TIE-1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for mTIE-1 Fc recombinant protein
Description: Soluble TIE-1 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO cells is a glycosylated disulfide-linked homodimeric polypeptide chain containing amino acids 23-749 and having a total molecular mass of 260kDa. The Mouse TIE-1/Fc monomer has a calculated molecular mass of approximately 105kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130kDa protein in SDS-PAGE under reducing conditions.The TIE1 Fc Chimera is purified by proprietary chromatographic techniques.
Introduction: TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
Introduction: TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
Product Categories/Family for mTIE-1 Fc recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
124,583 Da
NCBI Official Full Name
tyrosine-protein kinase receptor Tie-1
NCBI Official Synonym Full Names
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
NCBI Official Symbol
Tie1
NCBI Official Synonym Symbols
TIE; tie-1; D430008P04Rik
NCBI Protein Information
tyrosine-protein kinase receptor Tie-1; tyrosine kinase receptor 1
UniProt Protein Name
Tyrosine-protein kinase receptor Tie-1
UniProt Gene Name
Tie1
UniProt Synonym Gene Names
Tie; Tie-1
UniProt Entry Name
TIE1_MOUSE
Uniprot Description
TIE1: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; TK group; Tie family
Cellular Component: membrane; integral to membrane; plasma membrane
Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: blood vessel development; negative regulation of angiogenesis; response to retinoic acid; in utero embryonic development; angiogenesis; vasculogenesis; negative regulation of cell migration; protein amino acid phosphorylation; phosphorylation; plasma membrane fusion
Research Articles on mTIE-1 Fc
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Product Notes
The mTIE-1 Fc tie1 (Catalog #AAA142793) is a Recombinant Protein produced from Chinese Hamster Ovarian Cells (CHO) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TIE-1 Fc Chimera, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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