T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) Recombinant Protein | TIAM1 recombinant protein

Recombinant Human T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) , partial

• Gene Names: TIAM1; TIAM-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1); Recombinant Human T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1); partial; TIAM1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,531

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 115583670
• NCBI GeneID: 7074
• NCBI Accession #: NP_003244.2
• NCBI GenBank Nucleotide #: NM_003253.3
• UniProt Accession #: Q13009; Q17RT7; B7ZLR6; F5GZ53
• Molecular Weight: 170,580 Da
• NCBI Official Full Name: T-lymphoma invasion and metastasis-inducing protein 1 isoform 1
• NCBI Official Synonym Full Names: T cell lymphoma invasion and metastasis 1
• NCBI Official Symbol: TIAM1
• NCBI Official Synonym Symbols: TIAM-1
• NCBI Protein Information: T-lymphoma invasion and metastasis-inducing protein 1
• UniProt Protein Name: T-lymphoma invasion and metastasis-inducing protein 1
• Protein Family: T-lymphoma invasion and metastasis-inducing protein
• UniProt Gene Name: TIAM1
• UniProt Synonym Gene Names: TIAM-1

NCBI Description

This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]

Uniprot Description

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.