Rabbit anti-Human, Mouse MFSD8 Polyclonal Antibody | anti-MFSD8 antibody

MFSD8 Rabbit Polyclonal

Cat. Num. AAA7601388

• Gene Names: MFSD8; CCMD; CLN7
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MFSD8; Polyclonal Antibody; MFSD8 Rabbit Polyclonal; anti-MFSD8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 518

• Applicable Applications for anti-MFSD8 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Major facilitator superfamily domain containing 8
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue slide using MBS7601388 (MFSD8 Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7601388 (MFSD8 Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 22749525
• NCBI GeneID: 256471
• NCBI Accession #: NP_689991.1
• NCBI GenBank Nucleotide #: NM_152778.2
• Molecular Weight: 17,092 Da
• NCBI Official Full Name: major facilitator superfamily domain-containing protein 8
• NCBI Official Synonym Full Names: major facilitator superfamily domain containing 8
• NCBI Official Symbol: MFSD8
• NCBI Official Synonym Symbols: CCMD; CLN7
• NCBI Protein Information: major facilitator superfamily domain-containing protein 8
• UniProt Protein Name: Major facilitator superfamily domain-containing protein 8
• Protein Family: Major facilitator superfamily domain-containing protein
• UniProt Gene Name: MFSD8
• UniProt Synonym Gene Names: CLN7
• UniProt Entry Name: MFSD8_HUMAN

NCBI Description

This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]

Uniprot Description

MFSD8: May be a carrier that transport small solutes by using chemiosmotic ion gradients (Potential). Defects in MFSD8 are the cause of neuronal ceroid lipofuscinosis type 7 (CLN7). A form of late infantile neuronal ceroid lipofuscinosis. CNL are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The patterns most often observed CLN7 are mixed combinations of granular, curvilinear, fingerprint, and rectilinear profiles. The clinical course includes progressive dementia, seizures, and progressive visual failure. Belongs to the major facilitator superfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q28.2

Cellular Component: integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; nucleoplasm

Biological Process: lysosome organization and biogenesis; transmembrane transport

Disease: Ceroid Lipofuscinosis, Neuronal, 7; Macular Dystrophy With Central Cone Involvement