Transferrin Receptor 2 (TFR2) Recombinant Protein | TFR2 recombinant protein

Recombinant Transferrin Receptor 2 (TFR2)

Cat. Num. AAA2105256

• Gene Names: Tfr2; Trfr2
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Transferrin Receptor 2 (TFR2); Recombinant Transferrin Receptor 2 (TFR2); HFE3; TFRC2; TFR2 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic Expression
• Purity/Purification: > 95%
• Form/Format: Freeze-Dried Powder; 20mM Tris, 150mM NaCl, pH8.0, Containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Sequence Positions: His493~Asn785
• Sequence Length: 798

• Applicable Applications for TFR2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Species: Mouse
• Tag: N-terminal His-Tag
• Isoelectric Point: 6.7
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Subcellular Location: Membrane, Cytoplasm
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for TFR2 recombinant protein

Tumor immunity

NCBI and Uniprot Product Information

• NCBI GI #: 20140821
• NCBI GeneID: 50765
• UniProt Accession #: Q9JKX3
• Molecular Weight: Predicted MW: 36.8kDa; Accurate MW: 37kDa
• NCBI Official Full Name: Transferrin receptor protein 2
• NCBI Official Synonym Full Names: transferrin receptor 2
• NCBI Official Symbol: Tfr2
• NCBI Official Synonym Symbols: Trfr2
• NCBI Protein Information: transferrin receptor protein 2
• UniProt Protein Name: Transferrin receptor protein 2
• Protein Family: Transferrin receptor protein
• UniProt Gene Name: Tfr2
• UniProt Synonym Gene Names: Trfr2; TfR2
• UniProt Entry Name: TFR2_MOUSE

Uniprot Description

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; cell; cytoplasm; plasma membrane; integral to membrane

Molecular Function: transferrin receptor activity

Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis