Treacle protein (Tcof1) Recombinant Protein | Tcof1 recombinant protein

Recombinant Mouse Treacle protein (Tcof1) , partial

• Gene Names: Tcof1; treacle; AA408847; AW209012
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Treacle protein (Tcof1); Recombinant Mouse Treacle protein (Tcof1); partial; Tcof1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1320

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Tcof1 recombinant protein

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 6755742
• NCBI GeneID: 21453
• NCBI Accession #: NP_035682.1
• NCBI GenBank Nucleotide #: NM_011552.3
• UniProt Accession #: O08784; O08857
• Molecular Weight: 135,001 Da
• NCBI Official Full Name: treacle protein isoform 2
• NCBI Official Synonym Full Names: treacle ribosome biogenesis factor 1
• NCBI Official Symbol: Tcof1
• NCBI Official Synonym Symbols: treacle; AA408847; AW209012
• NCBI Protein Information: treacle protein
• UniProt Protein Name: Treacle protein
• Protein Family: Treacle protein
• UniProt Gene Name: Tcof1

Uniprot Description

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.