TAR DNA Recombinant Protein | TARDBP recombinant protein

Recombinant Human TAR DNA Binding Protein, (1-414 a.a.)

Cat. Num. AAA147172

• Gene Names: TARDBP; ALS10; TDP-43
• Purity: Greater than 85% as determined by SDS-PAGE
• Synonyms: TAR DNA; Recombinant Human TAR DNA Binding Protein; (1-414 a.a.); ALS10; TDP43; TAR DNA-binding protein 43; TDP-43; TARDBP; TARDBP (1-414) Human; TAR DNA Binding Protein (1-414 a.a.) Human Recombinant; TARDBP recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE
• Form/Format: Sterile filtered colorless solution; Protein solution (0.25mg/ml) containing 20mM Tris-HCl (pH8.0), 0.1M NaCl, 1mM DTT, 1mM EDTA and 10% glycerol
• Sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM.
• Sequence Length: 414

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles

Related Product Information for TARDBP recombinant protein

Description: TARDBP Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 414 amino acids (1-414 a.a) and having a molecular mass of 44.7kDa.
TARDBP is purified by proprietary chromatographic techniques.
Introduction: TARDNA Binding Protein (TARDBP) was initially recognized as a transcriptional repressorwhich binds to chromosomally integrated TAR DNA and represses HIV-1transcription. In addition, TARDBP has been detected in individuals identifiedwith chronic traumatic encephalopathy as well, which is a condition that oftenimitates ALS and hasbeen related with athletes who have experienced multiple concussions and othertypes of head injury.TARDBPhas been shown to bind both DNA and RNA, it has multiple functions intranscriptional repression, pre-mRNA splicing and translational regulation.

Product Categories/Family for TARDBP recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; TAR DNA; TARDBP (1-414) Human

NCBI and Uniprot Product Information

• NCBI GI #: 20140568
• NCBI GeneID: 23435
• UniProt Accession #: Q13148; Q53H27; Q6FI92; Q96DJ0; A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12
• Molecular Weight: 31,808 Da
• NCBI Official Full Name: TAR DNA-binding protein 43
• NCBI Official Synonym Full Names: TAR DNA binding protein
• NCBI Official Symbol: TARDBP
• NCBI Official Synonym Symbols: ALS10; TDP-43
• NCBI Protein Information: TAR DNA-binding protein 43
• UniProt Protein Name: TAR DNA-binding protein 43
• Protein Family: TAR DNA-binding protein
• UniProt Gene Name: TARDBP
• UniProt Synonym Gene Names: TDP43; TDP-43

NCBI Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Uniprot Description

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.