Pyr41 small molecule

Pyr41

Cat. Num. AAA808035

• Purity: >98%
• Synonyms: Pyr41; E1 UAE inhibitor; Ethyl 4-{(4Z)-4-[(5-nitro-2-furyl)methylene]-3; 5-dioxo-1-pyrazolidinyl}benzoate; PYR-41; 4[4-(5-Nitro-furan-2-ylmethylene)-3; 5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester; Pyr41 small molecule

• Host: Synthetic
• Purity/Purification: >98%
• Form/Format: Brown Powder

• Solubility: Soluble in 25 mg/ml DMSO
• CAS Number: 418805-02-4
• Molecular Formula: C17H13N3O7
• SMILES: CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2
• InChI: 1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
• InChI Key: ARGIPZKQJGFSGQ-LCYFTJDESA-N
• PubChem CID: 5335621
• Preparation and Storage: Store at -20 degree C.

Chemical Structure

(Chemical structure of Pyr41 (SIH-330), a E1 UAE inhibitor. CAS #: 418805-02-4. Molecular Formula: C17H13N3O7 . Molecular Weight: 371.3 g/mol.)

Related Product Information for Pyr41 small molecule

Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 uM) with little or no activity against E2 or E3. Cell permeable.

Product Categories/Family for Pyr41 small molecule

Small Molecules; Inhibitor; Cancer; Apoptosis

References

1. Yang Y., et al. (2007) Cancer Res. 67: 9472. 2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.