Chemical Structure
(Chemical structure of 17-DMAG (SIH-114), a Hsp90 inhibitor. CAS #: 467214-20-6. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol.)
17-DMAG small molecule
17-DMAG
Purity
>98% (TLC); NMR conforms
Synonyms
17-DMAG; Hsp90 inhibitor; Alvespimycin; 17DMAG; 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; 17-desmethoxy-17-n; n-dimethylaminoethylamino-geldanamycin; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17-Dimethylaminoethylamino; 17-Demethoxygeldanamycin; [(3R; 5S; 6R; 7S; 8E; 10S; 11S; 12Z; 14E)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5; 11-dimethoxy-3; 7; 9; 15-tetramethyl-16; 20; 22-trioxo-17-azabicyclo[16.3.1]docosa-1(21); 8; 12; 14; 18-pentaen-10-yl] carbamate; 17-DMAG small molecule
Host
Synthetic
Purity/Purification
>98% (TLC); NMR conforms
Form/Format
Purple Solid
Solubility
Soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml)
CAS Number
467214-20-6
Molecular Formula
C32H48N4O8
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
InChI
1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
InChI Key
KUFRQPKVAWMTJO-LMZWQJSESA-N
PubChem CID
5288674
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of 17-DMAG (SIH-114), a Hsp90 inhibitor. CAS #: 467214-20-6. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol.)
Chemical Structure
(Chemical structure of 17-DMAG (SIH-114), a Hsp90 inhibitor. CAS #: 467214-20-6. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol.)
Related Product Information for 17-DMAG small molecule
17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
Product Categories/Family for 17-DMAG small molecule
References
1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077. 2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381. 3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.
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Product Notes
The 17-DMAG (Catalog #AAA807921) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "17-DMAG, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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