Chemical Structure
(Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol.)
Pyr3 small molecule
Pyr3
Purity
>98%
Synonyms
Pyr3; TRPC3 Channel blocker; Ethyl 1-{4-[(2; 3; 3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; Pyr3 small molecule
Host
Synthetic
Purity/Purification
>98%
Form/Format
White solid
Solubility
Soluble to 100 mM in DMSO
CAS Number
1160514-60-2
Molecular Formula
C16H11Cl3F3N3O3
SMILES
CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
InChI
1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChI Key
RZHGONNSASQOAY-UHFFFAOYSA-N
PubChem CID
56964346
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol.)
Chemical Structure
(Chemical structure of Pyr3 (SIH-306), a TRPC3 Channel blocker. CAS #: 1160514-60-2. Molecular Formula: C16H11Cl3F3N3O3. Molecular Weight: 456.63 g/mol.)
Related Product Information for Pyr3 small molecule
Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
Product Categories/Family for Pyr3 small molecule
References
1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.
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Product Notes
The Pyr3 (Catalog #AAA808011) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pyr3, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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