Chemical Structure
(Chemical structure of E-4031 (SIH-317), a Herg channel blocker. CAS #: 113558-89-7. Molecular Weight: 510.5 g/mol.)
E-4031 small molecule
E-4031
Purity
>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms
Synonyms
E-4031; Herg channel blocker; N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride; dihydrate; E-4031 small molecule
Host
Synthetic
Purity/Purification
>98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms
Form/Format
White solid
Solubility
Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml)
CAS Number
113558-89-7
Molecular Formula
C21H27N3O3S-2HCl-2H2O
SMILES
CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.O.O.Cl.Cl
InChI
1S/C21H27N3O3S.2ClH.2H2O/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;;;/h3-9,18,23H,10-15H2,1-2H3;2*1H;2*1H2
InChI Key
AJNFQUKPBCGJKX-UHFFFAOYSA-N
PubChem CID
5312116
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of E-4031 (SIH-317), a Herg channel blocker. CAS #: 113558-89-7. Molecular Weight: 510.5 g/mol.)
Chemical Structure
(Chemical structure of E-4031 (SIH-317), a Herg channel blocker. CAS #: 113558-89-7. Molecular Weight: 510.5 g/mol.)
Related Product Information for E-4031 small molecule
E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
Product Categories/Family for E-4031 small molecule
References
1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68. 2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148. 3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215. 4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503. 5. Miyake K., et al. (1990) J Med Chem. 33: 903.
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Product Notes
The E-4031 (Catalog #AAA808022) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "E-4031, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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