NTRK1 sirna

NTRK1 siRNA (Rat)

Cat. Num. AAA8224413

• Gene Names: Ntrk1; Trk
• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: NTRK1; NTRK1 siRNA (Rat); TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; NTRK1 sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: NTRK1 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 799

• Applicable Applications for NTRK1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat NTRK1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for NTRK1 sirna

siRNA to inhibit NTRK1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 11024666
• NCBI GeneID: 59109
• NCBI Accession #: NP_067600.1
• NCBI GenBank Nucleotide #: NM_021589.1
• UniProt Accession #: P35739
• Molecular Weight: 87,252 Da
• NCBI Official Full Name: high affinity nerve growth factor receptor
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 1
• NCBI Official Symbol: Ntrk1
• NCBI Official Synonym Symbols: Trk
• NCBI Protein Information: high affinity nerve growth factor receptor
• UniProt Protein Name: High affinity nerve growth factor receptor
• Protein Family: High affinity nerve growth factor receptor
• UniProt Gene Name: Ntrk1
• UniProt Synonym Gene Names: Trk; Trka; Trk-A
• UniProt Entry Name: NTRK1_RAT

NCBI Description

a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]

Uniprot Description

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Oncoprotein; TK group; Trk family

Cellular Component: protein complex; cell surface; integral to plasma membrane; late endosome membrane; early endosome; dendrite; Golgi membrane; cell soma; axon; early endosome membrane; cytoplasm; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex

Molecular Function: neurotrophin p75 receptor binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; protein-tyrosine kinase activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; kinase binding; ATP binding

Biological Process: circadian rhythm; response to nicotine; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; sensory perception of pain; olfactory nerve development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; response to radiation; sympathetic nervous system development; learning and/or memory; negative regulation of neuron apoptosis; response to axon injury; detection of temperature stimulus involved in sensory perception of pain; response to electrical stimulus; response to hydrostatic pressure; aging; response to nutrient levels; response to drug; nervous system development; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of angiogenesis; positive regulation of programmed cell death; response to ethanol; B cell differentiation; positive regulation of Ras protein signal transduction; response to activity