Typical Testing Data/Standard Curve (for reference only)
Rat TRK A ELISA Kit | NTRK1 elisa kit
Rat TRK A ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Background: Tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain. TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor. TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC. Also, there are other neurotrophic factors structurally related to NGF: BDNF (for Brain-Derived Neurotrophic Factor), NT-3 (for Neurotrophin-3) and NT-4 (for Neurotrophin-4). While TrkA mediates the effects of NGF, TrkB is bound and activated by BDNF, NT-4, and NT-3. Further, TrkC binds and is activated by NT-3. TrkA receptor was found in kehumanoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.
NCBI and Uniprot Product Information
NCBI Description
a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]
Uniprot Description
TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.
Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; TK group; Trk family
Cellular Component: cell surface; protein complex; integral to plasma membrane; late endosome membrane; early endosome; dendrite; Golgi membrane; cell soma; early endosome membrane; axon; cytoplasm; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex
Molecular Function: neurotrophin p75 receptor binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; protein-tyrosine kinase activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; kinase binding; ATP binding
Biological Process: response to nicotine; circadian rhythm; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; sensory perception of pain; olfactory nerve development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; response to radiation; sympathetic nervous system development; learning and/or memory; response to axon injury; negative regulation of neuron apoptosis; response to electrical stimulus; detection of temperature stimulus involved in sensory perception of pain; response to hydrostatic pressure; aging; response to nutrient levels; response to drug; nervous system development; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of angiogenesis; positive regulation of programmed cell death; response to ethanol; B cell differentiation; response to activity; positive regulation of Ras protein signal transduction
Research Articles on NTRK1
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Product Notes
The Rat NTRK1 ntrk1 (Catalog #AAA824745) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA824745 ELISA Kit recognizes Rat NTRK1. AAA Biotech's TRK A can be used in a range of immunoassay formats including, but not limited to, Sandwich ELISA (SE). Researchers should empirically determine the suitability of the NTRK1 ntrk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRK A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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