Chromostatin Peptide | CHGA peptide

Chromostatin (bovine) (Chromogranin A (124-143)) (CGA, CHG A, Pancreastatin, Parathyroid secretory protein 1, Pituitary secretory protein I, Vasostatin, SPI)

Cat. Num. AAA658876

• Gene Names: CHGA; CGA
• Reactivity: Bovine
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: Chromostatin; Chromostatin (bovine) (Chromogranin A (124-143)) (CGA; CHG A; Pancreastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Vasostatin; SPI); CHGA peptide

• Host: Synthetic peptide
• Reactivity: Bovine
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Ser-Asp-Glu-Asp-Ser-Asp-Gly-Asp-Arg-Pro-Gln-Ala-Ser-Pro-Gly-Leu-Gly-Pro-Gly-Pro
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for CHGA peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 4502805
• NCBI GeneID: 1113
• NCBI Accession #: NP_001266.1
• NCBI GenBank Nucleotide #: NM_001275.3
• UniProt Accession #: P10645; Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9
• Molecular Weight: 50,688 Da
• NCBI Official Full Name: chromogranin-A preproprotein
• NCBI Official Synonym Full Names: chromogranin A (parathyroid secretory protein 1)
• NCBI Official Symbol: CHGA
• NCBI Official Synonym Symbols: CGA
• NCBI Protein Information: chromogranin-A; SP-I; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A)
• UniProt Protein Name: Chromogranin-A
• Protein Family: Chromogranin
• UniProt Gene Name: CHGA
• UniProt Synonym Gene Names: CgA; SP-I
• UniProt Entry Name: CMGA_HUMAN

NCBI Description

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit structure: Interacts with SCG3

By similarity.

Subcellular location: Cytoplasmic vesicle › secretory vesicle lumen

By similarity. Cytoplasmic vesicle › secretory vesicle membrane

By similarity. Secreted. Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions

By similarity.

Post-translational modification: Sulfated on tyrosine residues and/or contains sulfated glycans.O-glycosylated with core 1 or possibly core 8 glycans. Ref.16 Ref.20

Miscellaneous: Binds calcium with a low-affinity.

Sequence similarities: Belongs to the chromogranin/secretogranin protein family.