MEKK2 Blocking Peptide | MAP3K2 blocking peptide

MEKK2 Blocking Peptide

Cat. Num. AAA822594

• Gene Names: MAP3K2; MEKK2; MEKK2B
• Reactivity: Human, Mouse, Rat
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: MEKK2; MEKK2 Blocking Peptide; MAPKKK2; Mitogen-activated protein kinase kinase kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MAP3K2 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 619

• Applicable Applications for MAP3K2 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for MAP3K2 blocking peptide

The peptide is used to block Anti-MEKK2 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 85838511
• NCBI GeneID: 10746
• NCBI Accession #: NP_006600.3
• NCBI GenBank Nucleotide #: NM_006609.4
• UniProt Accession #: Q9Y2U5; Q53QL9; Q53S75; Q59GZ6; Q8NC32; Q9NYK3; B9EG87
• Molecular Weight: 69,741 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 2
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 2
• NCBI Official Symbol: MAP3K2
• NCBI Official Synonym Symbols: MEKK2; MEKK2B
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 2; MEKK 2; MEK kinase 2; MAP/ERK kinase kinase 2; MAPK/ERK kinase kinase 2
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 2
• UniProt Gene Name: MAP3K2
• UniProt Synonym Gene Names: MAPKKK2; MEKK2; MEK kinase 2; MEKK 2
• UniProt Entry Name: M3K2_HUMAN

NCBI Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Uniprot Description

MEKK2: a protein kinase of the STE11 family. Phosphorylates and activates MEK5. Involved in growth factor stimulated cell proliferation and differentiation.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Protein kinase, STE; Kinase, protein; STE group; STE11 family

Chromosomal Location of Human Ortholog: 2q14.3

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: activation of MAPKK activity; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; activation of JNK activity