SLC26A4 sirna

SLC26A4 siRNA (Human)

Cat. Num. AAA8235993

• Gene Names: SLC26A4; EVA; PDS; DFNB4; TDH2B
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC26A4; SLC26A4 siRNA (Human); PDS; Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4; SLC26A4 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC26A4 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 349

• Applicable Applications for SLC26A4 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC26A4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC26A4 sirna

siRNA to inhibit SLC26A4 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 4505697
• NCBI GeneID: 5172
• NCBI Accession #: NP_000432.1
• NCBI GenBank Nucleotide #: NM_000441.1
• UniProt Accession #: O43511; O43170; B7Z266
• Molecular Weight: 39,267 Da
• NCBI Official Full Name: pendrin
• NCBI Official Synonym Full Names: solute carrier family 26 (anion exchanger), member 4
• NCBI Official Symbol: SLC26A4
• NCBI Official Synonym Symbols: EVA; PDS; DFNB4; TDH2B
• NCBI Protein Information: pendrin
• UniProt Protein Name: Pendrin
• Protein Family: Pendrin
• UniProt Gene Name: SLC26A4
• UniProt Synonym Gene Names: PDS
• UniProt Entry Name: S26A4_HUMAN

NCBI Description

Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC26A4: Sodium-independent transporter of chloride and iodide. Defects in SLC26A4 are a cause of Pendred syndrome (PDS). PDS is an autosomal recessive disorder characterized by congenital sensorineural hearing loss combined with thyroid goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness is most often associated with a Mondini cochlear defect. Defects in SLC26A4 are the cause of deafness autosomal recessive type 4 (DFNB4); also known as vestibular aqueduct syndrome (EVA). DFNB4 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane

Molecular Function: iodide transmembrane transporter activity; chloride transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity

Biological Process: regulation of protein localization; sensory perception of sound; iodide transport; inorganic anion transport; regulation of pH; sulfate transport

Disease: Pendred Syndrome; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct