Western Blot (WB)
(Anti-CCR3 antibody, MBS176863, Western blottingLane 1: K562 Cell LysateLane 2: RAJI Cell Lysate )
Rabbit anti-Human CCR3 Polyclonal Antibody | anti-CCR3 antibody
Anti-CCR3 antibody
IHC-P: Concentration: 0.5-1ug/ml; Tested Species: Human; Antigen Retrieval: By Heat
ICC: Concentration: 0.5-1ug/ml; Tested Species: Human
Tested Species: In-House tested species with positve results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end user.
Antibody can be supported by Chemiluminescent Kit MBS176460 in WB, supporter by MBS176451 in IHC-P and ICC.
Western Blot (WB)
(Anti-CCR3 antibody, MBS176863, Western blottingLane 1: K562 Cell LysateLane 2: RAJI Cell Lysate )
Western Blot (WB)
(Anti-CCR3 antibody, MBS176863, Western blottingLane 1: K562 Cell LysateLane 2: RAJI Cell Lysate )
Immunohistochemistry (IHC)
(Anti-CCR3 antibody, MBS176863, IHC(P)IHC(P): Human Tonsil Tissue )
Immunohistochemistry (IHC)
(Anti-CCR3 antibody, MBS176863, IHC(P)IHC(P): Human Tonsil Tissue )
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Uniprot Description
CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, cytokine; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; viral reproduction; cellular defense response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; chemotaxis
Research Articles on CCR3
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Product Notes
The CCR3 ccr3 (Catalog #AAA176863) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CCR3 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CCR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). WB: Concentration: 0.1-0.5ug/ml; Tested Species: Human IHC-P: Concentration: 0.5-1ug/ml; Tested Species: Human; Antigen Retrieval: By Heat ICC: Concentration: 0.5-1ug/ml; Tested Species: Human Tested Species: In-House tested species with positve results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end user. Antibody can be supported by Chemiluminescent Kit MBS176460 in WB, supporter by MBS176451 in IHC-P and ICC. Researchers should empirically determine the suitability of the CCR3 ccr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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