SLC26A1 sirna

SLC26A1 siRNA (Human)

Cat. Num. AAA8209879

• Gene Names: SLC26A1; EDM4; SAT1; SAT-1
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC26A1; SLC26A1 siRNA (Human); SAT1; Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1; SLC26A1 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: SLC26A1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 701

• Applicable Applications for SLC26A1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLC26A1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC26A1 sirna

siRNA to inhibit SLC26A1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 20336272
• NCBI GeneID: 10861
• NCBI Accession #: NP_071325.2
• NCBI GenBank Nucleotide #: NM_022042.3
• UniProt Accession #: Q9H2B4; Q7Z5R3; Q96BK0; A8K9N2
• Molecular Weight: 24,962 Da
• NCBI Official Full Name: sulfate anion transporter 1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 26 (anion exchanger), member 1
• NCBI Official Symbol: SLC26A1
• NCBI Official Synonym Symbols: EDM4; SAT1; SAT-1
• NCBI Protein Information: sulfate anion transporter 1
• UniProt Protein Name: Sulfate anion transporter 1
• Protein Family: Sulfate anion transporter
• UniProt Gene Name: SLC26A1
• UniProt Synonym Gene Names: SAT1; SAT-1
• UniProt Entry Name: S26A1_HUMAN

NCBI Description

This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC26A1: High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: chloride transmembrane transporter activity; anion:anion antiporter activity; sulfate transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity

Biological Process: glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; sulfate transport; chloride transport; ion transport; pathogenesis; oxalate transport; transmembrane transport; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process